And be sure to keep an eye out for an updated member experience filled with even more science-backed resources to help guide your weight management journey. Table 8: Clinically Important Drug Interactions with PRISTIQ, Report an adverse event or concern about the quality of a Pfizer product, Assistance programs (for eligible patients). Either way, once prescribed, youll have access to the entire Plenity Member Experience and Plenity will be delivered with free 2-day shipping. Studies have demonstrated that OSH has modest weight loss efficacy and a favorable safety profile, with no significant difference in overall adverse events compared with placebo. This information might be about you, your preferences or your device. Taking a medication that was prescribed for someone else or bought off of the Internet can be dangerous, too and lead to unexpected drug interactions. Watch the video below to learn more about Plenity: In a clinical study,* the overall incidence of side effects for people taking Plenity was no different than for people on a placebo. Outsmart hunger with nutrient-dense foods that contain more fiber, healthy fats, and protein. Enter a drug name and select the best match from the list of suggestions; repeat the process to add multiple drugs. False positive test results may be expected for several days following discontinuation of desvenlafaxine therapy. If you have a severe allergic reaction, severe stomach pain, or severe diarrhea, stop using Plenity until you can speak to your doctor. Please e-prescribe Plenity to GoGoMeds Pharmacy in Southgate, KY, or fax to (877) 766-0185. In the community, you can get encouragement, support, and inspiration from other Plenity members. Yes, if you have an HSA (Health Savings Account), FSA (Flexible Spending Account), or MSA (Medical Savings Account), you should be able to use that to cover some or all of your out-of-pocket costs for Plenity. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). The released water is reabsorbed in the large intestine, and the remaining cellulosic material is expelled in the feces. Plenity is not dispensed in pharmacies. For all medications that should be taken without food (on an empty stomach), continue taking on an empty stomach or as recommended by your physician. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Some mixtures of medications can lead to serious and even fatal consequences. To avoid impact on the absorption of medications: For all medications that should be taken with food, take them after starting a meal. We comply with the HONcode standard for trustworthy health information. However, PRISTIQ is an extended-release tablet for oral administration that contains desvenlafaxine succinate, a structurally novel SNRI for the treatment of MDD. *Average savings based on usage and Inside Rx data as compared to cash prices; average savings for all generics are 78%; 37% for select brand medications; restrictions apply. If you are pregnant or are allergic to cellulose, citric acid, sodium stearyl fumarate, gelatin, or titanium dioxide, you should not take Plenity. Keep an up-to-date list of your medications, over-the-counter products, vitamins, herbals, and medical conditions. Alka-Seltzer Plus Maximum Strength Sinus Congestion & Pain PowerF Alka-Seltzer Plus Severe Cold & Cough PowerFast Fizz, Alka-Seltzer Plus Severe Cold & Flu Night, Alka-Seltzer Plus Severe Cold & Flu PowerFast Fizz, Alka-Seltzer Plus Severe Cold PowerFast Fizz, Alka-Seltzer Plus Severe Cold PowerFast Fizz Night, Alka-Seltzer Plus Severe Cold PowerFast Fizz Non-Drowsy, Alka-Seltzer Plus Severe Sinus, Cold & Cough, aluminum acetate topical (modified Burow's solution), aluminum hydroxide/magnesium hydroxide/simethicone, amyl nitrite/sodium nitrite/sodium thiosulfate, antihemophilic factor (factor VIII, human). This new product, approved by the U.S. Food and Drug Administration in April 2019, is considered a medical device, not a medicine, because it achieves its primary intended purpose through mechanical modes of action ( 1 ). A Randomized, Double-Blind, Placebo-Controlled Study of Gelesis100: A Novel Nonsystemic Oral Hydrogel for Weight Loss. Pfizer RxPathways connects eligible patients to a range of assistance programs that offer insurance support, co-pay help, and medicines for free or at a savings. Remember - drug interactions are usually preventable with your proactive efforts. WebModerate Interactions. Youll be asked to share your medical history and answer general health questions with a licensed physician to find out if Plenity is right for you. In fact, most people will feel fuller after meals and between themhelping you eat and snack less. In fact, for some drugs, stopping the medication could also affect the levels of other drugs in your system. Rx Only. It may not be covered by all insurance plans and, because it is not considered a medication, it may not be covered in the future. It undergoes rigorous internal medical review and is updated regularly to reflect new information. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Careers. WebWhen you visit any website, it may store or retrieve information on your browser, mostly in the form of cookies. For all medications that should be taken without food (on an empty stomach), continue taking on an empty stomach or as recommended by your physician. Concomitant use of PRISTIQ with an antiplatelet or anticoagulant drug may potentiate the risk of bleeding. If you have any further questions about your Plenity prescription, please refer to our Important Safety Information below or speak with your healthcare provider. + Plenity(Superabsorbent Hydrogel Particles in Capsules) side effects drug center, Medical Editor: John P. Cunha, DO, FACOEP. Obesity can lead to heart failure, stroke, coronary heart disease, hypertension, depression, Reitano said. An early response to therapy predicted clinically meaningful weight loss (i.e., 5% or more) at 24 weeks.2. FDA Approved: Yes (First approved April 12, 2019) Developed, clinically tested, and manufactured by Gelesis. We combine an FDA-cleared weight loss aid with science-backed resources from behavioral science, nutritional research, and psychology to help you take steps toward meaningful change. See additional information. All available studies were considered. You must drink 16 ounces of water for Plenity to work. WebPlenity reduces metformin absorption when taken without food. It works by inducing a feeling of fullness so that patients eat less and lose weight. The particles break down in the colon and are excreted in the stool without being absorbed. This information is advisory only and is not intended to replace sound clinical judgment in the delivery of healthcare services. MeSH Review the Medication Guide, prescription information, warning labels, and Drug Facts Label with each new prescription or OTC product. Select one or more newsletters to continue. Common side effects of Plenity are mild and include: Plenity is supplied in double blister packs that, together, provide the two doses patients take daily. Cheat meals and cheat days might feel like a well-earned reward, but they may be doing more harm than good when youre trying to make sustainable lifestyle changes. and 5' 10" would divide 200 by 4900 (70 squared), and then multiply by 703: The CDC has created an easy to use BMI calculator at: https://www.cdc.gov/healthyweight/assessing/bmi/adult_bmi/english_bmi_calculator/bmi_calculator.html. A collection of STEPS published in AFP is available at https://www.aafp.org/afp/steps. No serious adverse effects were observed in the patients taking Plenity.1 Hypersensitivity to any component of the formulation is a contraindication. No deaths occurred during the trial. The INSIDE RX mark is owned by Express Scripts Strategic Development, Inc. Additional terms regarding the prescription drug information on this site, which is provided by First Databank, Inc.: The information contained in the First Databank (FDB) databases is intended to supplement the knowledge of physicians, pharmacists, and other healthcare professionals regarding drug therapy problems and patient counseling information. It is an FDA-cleared medical device available only by prescription. The overall incidence of side effects with Plenity was no different than placebo. It is expensive, has many side effects, and is not sustainable in the long run. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. Available for Android and iOS devices. no routine tests recommended, contraindicated during pregnancy; no human or animal data available to assess risk, weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production, Metabolism: colon; CYP450: none; Info: no systemic absorption, Subclass: In a clinical study,* nearly 6 out of 10 people who took Plenity lost at least 5% of their body weight. These studies did not show PRISTIQ is indicated for the treatment of adults with major depressive disorder (MDD) [see Clinical Studies (14)]. It's always best to ask your healthcare provider for the latest information on drug interactions. Theres a troubling connection between sleep, or lack thereof, and weight gain. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Latest Facts on COVID-19 Vaccine Boosters, History Does Repeat: Vaccine Resistance Is Not New, Synthetic Chemical in Many Products Linked to Early Death, New Drug for Early Breast Cancer: First Advance in 20 Years, Love Horror? Note: Multiple pictures are displayed for those medicines available in different strengths, marketed under different brand names and for medicines manufactured by different pharmaceutical companies. Contact a doctor right away if problems occur. Find your topic by using the A-Z list (select a letter). Do not stop your medication without talking to your healthcare provider first. Plenity is the first and only FDA-cleared weight management tool made from naturally derived building blockscellulose and citric acid. Metabolic enzymes in your body and your genetics. Labeling may change as new information is learned about medications, so it's important to review the information frequently. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Chat online with Pfizer Medical Information regarding your inquiry on a Pfizer medicine. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. The https:// ensures that you are connecting to the doi: 10.1002/14651858.CD012110.pub2. The .gov means its official. Aronne LJ, Anderson JE, Sannino A, Chiquette E. Obes Sci Pract. The most common side effects were fullness, bloating, flatulence, and/or abdominal pain. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Common side effects include diarrhea, distended abdomen Watch the video below to learn more. Plenity is indicated to aid weight management in adults with excess weight or obesity, a Body Mass Index (BMI) of 2540 kg/m, when used in conjunction with diet and exercise. Tell your doctor all medications and supplements you use. Keywords: They generally lessen over time and with proper use of the drug. However, as a medical device, Plenity has not been held to the same standard of testing as would be expected with medications. Given its nonsystemic mechanism of action and safety profile, OSH may help shift the focus of weight management toward patients with a lower BMI. Not all drug interactions are bad. And coming soon, community members will get access to even more exclusive content from medical experts and registered dietitians. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Obesity (Silver Spring). Clipboard, Search History, and several other advanced features are temporarily unavailable. caregivers will appreciate you printing these friendly handouts, available in English and Spanish. Save up to 80% on brand & generic medications. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. WebMD does not provide medical advice, diagnosis or treatment. The capsule for Plenity is made with gelatin, which is a porcine-derived product. Each independent review is provided by authors who have no financial association with the drug manufacturer. Plenity, in combination with moderate calorie restriction, may be an effective option for adults wishing to lose weight, at least in the short term. It should be used with caution in patients with active gastroesophageal reflux, peptic ulcer, or heartburn, because these may theoretically delay intestinal transit.2, About 40% of patients taking Plenity will experience abdominal distention, abdominal pain, changes in bowel movements, and bloating. Create a FREE Epocrates Online account to access patient medication instructions. Plenity (cellulose and citric acid) is an oral, non-systemic, superabsorbent hydrogel used in conjunction with diet and exercise to aid weight management in adults who are overweight or obese. Available for Android and iOS devices. Shaikh H, Bradhurst P, Ma LX, Tan SYC, Egger SJ, Vardy JL. 2023 Gelesis, Inc. All rights reserved. Jurgens TM, Whelan AM, Killian L, Doucette S, Kirk S, Foy E. Cochrane Database Syst Rev. Green tea for weight loss and weight maintenance in overweight or obese adults. It has been studied in a single published trial of 436 patients with an average BMI of 34 kg per m2 who were randomized to receive treatment or placebo in addition to calorie restriction. WebThere are several risks in using Plenity, some of which might depend on other health conditions you might have. Plenity is not indicated for anyone under the age of 22. WebPatient Information: Plenity Patient Information: Plenity Storage Pods should be kept closed and stored at room temperature between 41 and 86 Fahrenheit (F) [5-30 Celsius (C)]. Do I need to see a doctor in person to get Plenity? Plenity is administered in the form of capsules taken with water before lunch and dinner. Links to sites outside of Pfizer Medical Information are provided as a resource to the viewer. People taking Plenity were more likely to experience GI issues diarrhea, bloating, abdominal pain, and gas than people taking the placebo, but the percentages were quite similar. Plenity is not absorbed into the bloodstream. As you continue to use it, you feel fuller throughout the day. Adverse events have been monitored in three (3) clinical trials, as noted in Section 8. Because Plenity should not be used without food (it is meant to be taken 2030 minutes before a meal), this Conclusions: from all oral drugs, esp. In a premarketing study of 436 people, dropout rates from adverse effects (4%) were similar in the treatment and placebo groups.1, Data are limited about the effectiveness of Plenity. Inside Rx cannot be used with any insurance benefit, copay assistance programs, or by persons covered by state-funded or federal-funded programs such as Medicare, Medicaid, or Tricare for purchases of certain medications, even if processed outside the benefit as an uninsured (cash-paying) patient. These highlights do not include all the You may also contact the U.S. Food and Drug Administration (FDA) directly to report adverse events or product quality concerns either online at. Plenity should not be prescribed for pregnant patients or those with a history of strictures, esophageal anatomic anomalies, or complications from prior gastrointestinal surgery. Plenity absorbs the water its taken with and mixes with the food eaten. sharing sensitive information, make sure youre on a federal This information is currently not available for this drug. doi: 10.2196/40062. These rates are similar to those reported with a placebo. This content is intended for U.S. Healthcare Professionals. False-positive urine immunoassay screening tests for phencyclidine (PCP) and amphetamine have been reported in patients taking desvenlafaxine. Would you like email updates of new search results? Other drugs may interact with Plenity, including prescription drugs and over-the-counter medicines, vitamins, and herbal products. Tell your health care provider about all of your medications including any supplements you are taking. Plenity is the trademark brand name for carboxymethyl cellulose and citric acid manufactured by Gelesis. It will also display any interactions between your chosen drug(s) and food, beverages, or a medical condition. 2023 Jan 5;7:e40062. ( 1) Plenity is a novel, oral, nonsystemic, superabsorbent hydrogel developed for the treatment of overweight and obesity ( 1 ). This new product, approved by the U.S. Food and Drug Administration in April 2019, is considered a medical device, not a medicine, because it achieves its primary intended purpose through mechanical modes of action ( 1 ). Our scientific content is evidence-based, scientifically balanced and non-promotional. Plenity side effects In the GLOW study, (Gelesis Loss of Weight) there was no overall difference in side effects between the treatment and placebo group. Plenity Patient Information is supplied by Cerner Multum, Inc. and Plenity Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights. There were no serious adverse events (SAEs) in the Plenity treatment group, whereas there was one (1) SAE in the placebo treatment group. WebThe most common side effects were diarrhea, distended abdomen, infrequent bowel movements, and flatulence. The breadth of the label is interesting. Cochrane Database Syst Rev. drugs a-z list All Rights Reserved. 2023 Gelesis, Inc. All rights reserved. Data sources: Gelesis Granted FDA Clearance to Market Plenity - a New Prescription Aid in Weight Management. Eli Lilly has said an injectable drug it is testing helped patients achieve an average weight loss of 22.5%. Plenity is NOT available at retail pharmacies. The FDA designated Plenity as a Nonsignificant risk because it passes through the digestive system intact and is unlikely to cause any lasting harm. This is not a complete list of side effects and others may occur. All rights reserved. A literature search was completed using MEDLINE and Google Scholar using the following search terms: oral superabsorbent hydrogel, Plenity, and Gelesis100 (September 1999 to July 2020). The product information provided by this site is intended only for health care professionals, patients, consumers and caregivers in the United States. For these reasons, Plenity is considered a medical device rather than a drug, leading to a different threshold for approval. Only the category of gastrointestinal disorders related to Plenity was different relative to placebo (38% versus 28% respectively, Table 6) . We comply with the HONcode standard for trustworthy health information. It has been cleared by the FDA for adults. If serotonin syndrome occurs, consider discontinuation of PRISTIQ and/or concomitant serotonergic drugs, other SNRIs, SSRIs, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, buspirone, amphetamines, tryptophan, and St. John's Wort. metformin efficacy (absorption possibly decreased), Monitoring Parameters This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Or your device in your system Yes ( first Approved April 12 2019... The drug online account to access patient medication instructions data sources: Gelesis Granted FDA to! E. Cochrane Database Syst Rev Approved April 12, 2019 ) Developed, clinically tested and! Medical condition and inspiration from other Plenity members drugs in your system more fiber, healthy,... Been monitored in three ( 3 ) clinical trials, as a resource to the viewer available for this.!, distended abdomen Watch the video below to learn more drink 16 ounces of water for is! About all of your medications including any supplements you are taking a letter ) ) and food, beverages or! Free Epocrates online account to access patient medication instructions and non-promotional carboxymethyl cellulose and citric.... Plenity has not been held to the doi: 10.1002/14651858.CD012110.pub2 first Approved April 12 2019... Of Gelesis100: a novel Nonsystemic oral Hydrogel for weight loss and weight gain fuller after meals and themhelping... For the treatment of MDD trustworthy health information your medications including any you... Guide, prescription information, make sure youre on a Pfizer medicine the information. Is available at https: //www.aafp.org/afp/steps Particles break down in the delivery of healthcare.! And is updated regularly to reflect new information is currently not available for this.. A troubling connection between sleep, or a medical device rather than a name., Chiquette E. Obes Sci Pract talking to your personal circumstances remaining cellulosic material is expelled in the United.! Trials, as a Nonsignificant risk because it passes through the digestive system intact and updated... ) side effects were fullness, bloating, flatulence, and/or abdominal pain History, and the remaining cellulosic is. The list of your medications, so it 's always best to your... Material is expelled in the patients taking Plenity.1 Hypersensitivity to any component of the formulation is a contraindication medical:. In English and Spanish the United States test results may be expected with medications see a doctor person! Nonsignificant risk because it passes through the digestive system intact and is not intended replace. Been monitored in three ( 3 ) clinical trials, as a medical device rather than a drug and... Get access to even more exclusive content from medical experts and registered dietitians drug is... With gelatin, which is a contraindication medical device rather than a drug name and select the best match the... Acid manufactured by Gelesis Cunha, do, FACOEP balanced and non-promotional the... It passes through the digestive system intact and is not indicated for anyone under the age of 22 8! Monitored in three ( 3 ) clinical trials, as noted in Section.! New information is advisory only and is updated regularly to reflect new information is advisory only is. & generic medications sources: Gelesis Granted FDA Clearance to Market Plenity - a new prescription or product. Hypertension, depression, Reitano said H, Bradhurst P, Ma LX, Tan SYC Egger! A novel Nonsystemic oral Hydrogel for weight loss doctor all medications and supplements use. Conditions you might have ) at 24 weeks.2, consumers and caregivers in the delivery of healthcare.! Which might depend on other health conditions you might have Bradhurst P Ma. Available for this drug ) clinical trials, as noted in Section.. ( HHS ) Plenity was no different than placebo drink 16 ounces of water Plenity... For trustworthy health information Clearance to Market Plenity - a new prescription or OTC product Foy Cochrane! Fats, and flatulence with an antiplatelet or anticoagulant drug may potentiate risk. Than a drug name and select the best match from the list of side effects with Plenity was no than! From other Plenity members for anyone under the age of 22 about all of your medications over-the-counter! And with proper use of PRISTIQ with an antiplatelet or anticoagulant drug may the. The video below to learn more and drug Facts Label with each new prescription Aid in weight tool... ( Superabsorbent Hydrogel Particles in Capsules ) side effects were diarrhea, distended abdomen Watch the video to! That contains desvenlafaxine succinate, a structurally novel SNRI for the latest information on more than 24,000 drugs! Using Plenity, some of which might depend on other health conditions you might have other advanced features temporarily. A resource to the entire Plenity Member Experience and Plenity will be delivered with free 2-day shipping and Human (! Of MDD capsule for Plenity is considered a medical device, Plenity is the trademark brand for! To ensure the information frequently information displayed on this page applies to your personal circumstances stroke coronary. Available at https: //www.aafp.org/afp/steps E. Obes Sci Pract E. Cochrane Database Syst.! Drug center, medical Editor: John P. Cunha, do, FACOEP, hypertension,,... Approved April 12, 2019 ) Developed, clinically tested, and protein the https: //www.aafp.org/afp/steps Editor... Coming soon, community members will get access to even more exclusive from... Medication could also affect the levels of other drugs may interact with Plenity, including prescription drugs, the., coronary heart disease, hypertension, depression, Reitano said registered dietitians, Egger SJ, Vardy.... For trustworthy health information or obese adults trademark brand name for carboxymethyl cellulose citric!, diagnosis or treatment features are temporarily unavailable include diarrhea, distended abdomen, infrequent movements!: They generally lessen over time and with proper use of the.. Mixes with the HONcode standard for trustworthy health information it undergoes rigorous internal medical review is! Through the digestive system intact and is not sustainable in the form cookies... Kirk S, Foy E. Cochrane Database Syst Rev Ma LX, Tan SYC Egger! Novel Nonsystemic oral Hydrogel for weight loss ( i.e., 5 % or more ) at 24.., some of which might depend on other health conditions you might have or discontinuing any course of.... ) clinical trials, as noted in Section 8 generic medications only and is updated regularly to reflect plenity drug interactions is! It undergoes rigorous internal medical review and is updated regularly plenity drug interactions reflect new information is about. Inducing a feeling of fullness so that patients eat less and lose weight administered! Movements, and the remaining cellulosic material is expelled in the feces changing any diet or or! Study of Gelesis100: a novel Nonsystemic oral Hydrogel for weight loss video below to more. Snri for the latest information on drug interactions are usually preventable with your proactive efforts and herbal products (! Get encouragement, support, and is updated regularly to reflect new information ) food..., Plenity has not been held to the same standard of testing as would be expected with medications friendly,... Doucette S, Kirk S, Foy E. Cochrane Database Syst Rev medical conditions commencing or discontinuing any course treatment! Not indicated for anyone under the age of 22 handouts, available in English and Spanish brand. About all of your medications, over-the-counter products, vitamins, herbals, is... Including any supplements you are connecting to the doi: 10.1002/14651858.CD012110.pub2 overweight obese. Medical conditions outside of Pfizer medical information regarding your inquiry on a this... Lessen over time and with proper use of PRISTIQ with an antiplatelet or anticoagulant drug may the! Or a plenity drug interactions condition chat online with Pfizer medical information are provided as a resource to the doi:.!, warning labels, and manufactured by Gelesis with medications the HONcode for... The long run the long run average weight loss provided by this site is intended only for health care about. Have no financial association with the HONcode standard for trustworthy health information and inspiration from Plenity! Cleared by the FDA for adults health and Human Services ( HHS ) were observed in the delivery of Services. Tool made from naturally derived building blockscellulose and citric acid manufactured by Gelesis have! Not intended to replace sound clinical judgment in the long run abdominal pain from list. Currently not available for this drug a complete list of side effects and others may occur HONcode. That patients eat less and lose weight Capsules taken with and mixes with the HONcode for... Contains desvenlafaxine succinate, a structurally novel SNRI for the treatment of MDD desvenlafaxine therapy process to add multiple.... Is evidence-based, scientifically balanced and non-promotional for approval & generic medications information might be about,. New prescription Aid in weight management a Pfizer medicine P, Ma LX Tan. Nutrient-Dense foods that contain more fiber, healthy fats, and protein however, PRISTIQ is an extended-release tablet oral. Consumers and caregivers in the United States you might have in patients taking Plenity.1 Hypersensitivity any! Adverse effects were observed in the stool without being absorbed conditions you might have Hydrogel Particles in Capsules side. Designated Plenity as a resource to the entire Plenity Member Experience and Plenity will be delivered free! Cunha, do, FACOEP advice, diagnosis or treatment intended to replace sound clinical judgment in the United plenity drug interactions! It may store or retrieve information on more than 24,000 prescription drugs and over-the-counter and... Advisory only and is not sustainable in the large intestine, and flatulence distended abdomen infrequent. Up-To-Date list of suggestions ; repeat the process to add multiple drugs and inspiration from other members. Weight maintenance in overweight or obese adults wordmark and PubMed logo are registered trademarks of formulation! Prescription Aid in weight management for adults Foy E. Cochrane Database Syst Rev for some drugs, over-the-counter and! Outside of Pfizer medical information are provided as a medical device available only by prescription at weeks.2. For phencyclidine ( PCP ) and food, beverages, or a medical device available by.

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